Placebo Manufacturing

Eramol delivers comprehensive placebo manufacturing services to support blinded clinical trials across the UK, EU, and globally. From matched tablets and over-encapsulated capsules to liquid formulations and neat-fill API capsules, our expert team ensures that every placebo meets the highest quality, regulatory, and sensory standards, helping maintain the scientific credibility of your study.

Matched Placebo Tablets

Accurate placebo matching for reliable trial outcome

Eramol provides matched placebo tablets designed to replicate the appearance, size, shape, and coating of your active product:

• Custom tooling to match active tablet dimensions and appearance
• Tablet sizes: 5mm to 25mm diameter
• Manufacturing speeds: up to 40,000 tablets per hour
• Bespoke aqueous film coating for colour matching, including enteric and modified release coatings
• Placebo IMPD creation for regulatory submission

Our matched tablets ensure your blinded study design remains robust and credible.

Over-Encapsulation Services

Expert capsule blinding methodologies

Over-encapsulation conceals the contents of tablets or capsules inside opaque shells, creating visually identical products for blinded trials. Eramol’s services include:

• Existing placebo capsule formulations with stability data
• Wide selection of capsule shells and sizes
• Automated and semi-automated capsule filling
• Multiple tablets or capsules over-encapsulated into single shells
• Full regulatory support and documentation

Neat-Fill API Capsules

Rapid and precise early-phase manufacturing

Eramol offers neat-fill API capsule manufacturing, ideal for small-scale, early-phase trials where material reconciliation is critical:

• Manual and semi-automated capsule filling
• Small batch production for early-phase studies
• Rapid, flexible, and high-quality manufacturing for clinical trial timelines

Placebo Liquid Formulations

Sensory-perfect solutions for blinded liquid trials

Eramol develops liquid placebo formulations that match the visual, taste, texture, and olfactory characteristics of the active product:

• Oral and topical liquid manufacturing (solutions and suspensions)
• Nasal sprays and oral drops
• Bulk liquid pack-down via semi-automated filling lines
• Regulatory support and testing to ensure trial compliance

Regulatory Expertise & Quality Assurance

Eramol’s placebo manufacturing team integrates GMP and regulatory expertise throughout all stages of development and production:

• Compliance with UK and EU regulatory requirements
• Full support for IMPD creation and documentation
• Expertise in blinded study design and placebo matching
• Rapid, agile production to meet tight clinical timelines
• Quality oversight ensuring integrity, safety, and reproducibility

Why Choose Eramol for Placebo Manufacturing

• High-quality matched placebos: tablets, capsules, liquids
• Agile manufacturing: rapid response for early-phase and late-phase studies
• Regulatory-compliant operations with QP support
• Neat-fill capsule capabilities for early-phase APIs
• Expert packaging and blinding solutions integrated with clinical supply chain

Eramol is a trusted partner for placebo manufacturing, helping clinical trial sponsors maintain trial integrity, meet regulatory standards, and optimise study outcomes.

Contact Eramol

Ensure your clinical trial placebos are accurately matched, regulatory-compliant, and ready for blinded studies.